Live Better for Longer – Longevity by kingnature

Live longer and better

In the Longevity category, we are dedicated to extending your life span and health span. Discover our range of groundbreaking, unique and scientifically revolutionary supplements that aim to not only increase the number of years you live, but more importantly, maximize the quality. Here you'll find products specifically designed to support you on your journey to a full and healthy life.

What does longevity mean?

Longevity is currently on everyone's lips. The term simply means "living a long life". Who wouldn't want a long life? Or even better, a healthy and long life! Our well-being depends on both: the age we reach and the health we can enjoy. Accordingly, we are pursuing the following options:

Development of the longevity range

Our Longevity products are based on unique, patented combinations of plant substances that we have developed in our own research work. They provide your body with targeted support in two key areas of the biological ageing process:

Firstly, we focus on the ageing of cells (senolytics). Your body is supported in doing what it does naturally: renewing damaged cells. As you age, the renewal processes that are crucial to your cellular health slow down. That's why we've developed Senocure and Senofree, two nutrient blends that provide your body with the plant substances it needs to promote and maintain these renewal processes at cellular level. more on

For the first time, we are also offering a nutrient mixture that specifically supports the body in breaking down harmful chemical end products. These so-called AGE's (Advanced Glycation Endproducts) are known to promote numerous age-related diseases. They impair the normal function of organs and metabolic processes and are regarded as an established marker for biological age. AGEAWAY® supports your body down to the cellular level in detoxification and thus protects it from an accumulation of AGE's.

Here you will find valuable information about the ageing process and insights into our revolutionary research work.

Cellular aging and senolytics

At kingnature, we have been working since 2015 to develop natural solutions that allow us to a) live longer and b) above all, live better. Now, 10 years later, we have achieved our breakthrough. In the timeline below, you can find out how our groundbreaking product - the Longevity Box - came about!

The problem of cellular ageing

Human ageing is a gradual loss of the functions of various organ systems, which leads to them working less and less efficiently. This increases the risk of disease and eventually leads to death.

A central feature of ageing is the accumulation of severely damaged cells, known as senescent cells. These cells stop dividing but resist cell death, promote inflammation and create a harmful environment in the body. At a young age, the immune system efficiently removes senescent cells. However, immune cells also age and become senescent, gradually losing their ability to remove old cells.

Combating the ageing process is a major challenge. Ageing is a complex process caused by various damaging events that ultimately lead to cell failure and senescence. These include genetic instability, DNA damage, telomere shortening, oxidative damage to proteins and DNA, stress in the mitochondria and problems with protein regulation. Due to the complexity of cell ageing, it is difficult to imagine a natural solution without an innovative approach.

Our solution for cellular senescence

We decided to look for a small, effective natural molecule that supports the body in dealing with senescent cells so that they are either removed or their senescence is reversed to a healthy state.

Our research team combined modern, cost-effective methods with natural substances known for their safety and benefits. Through computer-assisted screening and cell experiments, we focused on a selection of substances that had the potential to influence cellular processes.

Over two years, we were able to show that two very specific compounds were consistently useful in different cell types: One showed pronounced senolytic activity, the other strong regenerative activity. This resulted in two nutrient mixtures: SenoFree® with senolytic activity and SenoXure® with regenerative properties.

Advanced Glycation End Products (AGE's)

Find out more about the development of our latest Longevity product, the AgeAway Shot, and how AGE's relate to ageing.

The role of AGE's in the ageing process

Advanced Glycation End Products, abbreviated to AGE's, means something like "end product of glycation" or "advanced saccharification end product". AGE's are formed both in the body and during frying and cooking as part of the so-called Maillard reaction, which is responsible for the characteristic browning and popular taste. In this process, proteins or fats combine with carbohydrates in a non-enzymatic (self-running) reaction that slowly leads to a barely reactive chemical end product via several intermediate¹.

The spontaneous formation of AGE's in the body and their uptake through food are relevant for health, as AGE's are considered to be a contributory cause of numerous diseases that are often attributed solely to the 'normal ageing process'. AGE's are very long-lived and accumulate in connective tissue, on cell walls and in the organs. They have unfavorable effects on cell structures and metabolic processes and can therefore also be described as harmful chemical end ^p2.

AGE's have the ability to change the structure and function of proteins and are therefore a component of ageing and inflammatory processes. AGE's can crosslink with each other through so-called crosslinking, which leads to hardening and wrinkling of the tissue. This is particularly evident in skin wrinkles or age spots. Another consequence of the accumulation of AGE's in the organs is impaired metabolism. The function of metabolic proteins, such as the insulin receptor, is impaired when AGE's block the corresponding receptors. Food substances that rely on enzymes can be impaired in their absorption, which can promote metabolic problems such as insulin resistance. A more complex consequence of AGE formation is chronic, subliminal inflammation (silent inflammation). This is because AGE molecules can bind to specific receptors on inflammatory cells (RAGE), triggering inflammatory signaling. This RAGE signaling may therefore be relevant for numerous age-related inflammatory³.

The accumulation of AGE's can be determined by a simple fluorescence measurement in the skin. This measurement is very accurate and is considered a reliable reference value in medicine for determining biological age. AGE levels increase with age and are promoted by high blood sugar, oxidative stress and frying or grilling foods. Although the breakdown of AGE's is difficult, it is not necessarily irreversible.

¹ IMD Labor Berlin, retrieved on September 27, 2024.

² Byun et al. (2017): Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases. Pharmacol Ther. 177: 44-55.

³ Chuah et al: Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases. Int J Inflammation 2013, 2013, p. 403460

Our solution to the problem of AGE's

Our innovative approach is based on plant substances that can inhibit the formation of AGE's (Advanced Glycation Endproducts) in the body and promote their breakdown. Through their targeted combination, we support the metabolism at various biochemical interfaces in order to reduce the effects of AGE's on the body. Our nutrient mix was developed in collaboration with Dr. Achim Refisch, who has been working intensively on ageing and related topics such as longevity and detox at cellular level for many years.

AGEAWAY® is formulated in such a way that the ingredients are tailored to all relevant mechanisms of action of AGE's. The plant substances influence AGE's at various levels: They can prevent their formation, inhibit their deposition in tissue or block their binding to cells, thereby reducing inflammatory processes, for example. At the same time, the degradation of existing AGE's can be promoted. The reduction of AGE's promotes good overall health. Particularly noteworthy is the protection of vascular cells from oxidative stress and the support of a normal metabolism.